(Z)-Pugnac

Name: ( Z )-Pugnac
Brand: Tocris Bioscience
SKU: 3384
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3384

(1)

Citations (24)

COA / SDS

O-GlcNAcase and β-hexosaminidase inhibitor

Key Product Details

Chemical Name:	O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate
Purity:	≥98%
Molecular Weight:	353.33 kDa

View Full Technical Details for (Z)-Pugnac

Technical Data
Citations / Reviews (1)

Biological Activity for (Z)-Pugnac

(Z)-Pugnac is an O-GlcNAc-β-N-acetylglucosaminidase (O-GlcNAcase) and β-hexosaminidase inhibitor (K_i values are 46 and 36 nM respectively) that increases O-GlcNAc levels ~ 2-fold in HT29 cells. Z-linked isomer is more potent than the E isomer.

Technical Data for (Z)-Pugnac

M. Wt	353.33 kDa
Formula	C₁₅H₁₉N₃O₇
Storage	Store at -20°C
Purity	≥98%
CAS Number	132489-69-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (Z)-Pugnac

Solubility

Soluble Soluble to 100 mM in DMSO

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References for (Z)-Pugnac

References are publications that support the biological activity of the product.

Dong and Hart Purification and characterization of an O-GlcNAc selective N-acetyl-β-D-glucosaminidase from rat spleen cytosol. J.Biol.Chem., 1994;269:19321 PMID: 8034696
Macauley et al. O-GlcNAcase uses substrate-assisted catalysis. J.Biol.Chem., 2005;280:25313 PMID: 15795231
Perreira et al. Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry. Bioorg.Med.Chem., 2006;14:837 PMID: 16214344