QX 314 chloride

Name: QX 314 chloride
Brand: Tocris Bioscience
SKU: 2313

Tocris Bioscience, part of Bio-Techne | Catalog # 2313

(3)

Citations (71)

COA / SDS

Na+ channel blocker

Key Product Details

Chemical Name:	N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride
Purity:	≥99%
Molecular Weight:	298.85 kDa

View Full Technical Details for QX 314 chloride

Technical Data
Citations / Reviews (3)

Biological Activity for QX 314 chloride

QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na⁺ channels.

Technical Data for QX 314 chloride

M. Wt	298.85 kDa
Formula	C₁₆H₂₇N₂OCl
Storage	Store at RT
Purity	≥99%
CAS Number	5369-03-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for QX 314 chloride

Solubility

Soluble Soluble to 100 mM in water

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References for QX 314 chloride

References are publications that support the biological activity of the product.

Y Li, G Missig, BC Finger, SM Landino, AJ Alexander, E Mokler, J Robbins, Y Manasian, W Kim, KS Kim, CJ McDougle, WA Carlezon, VY Bolshakov Maternal and Early Postnatal Immune Activation Produce Dissociable Effects on Neurotransmission in mPFC-Amygdala Circuits J. Neurosci., 2018;0(0):. 2018 PMID: 29491010
Stichartz et al. The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J.Gen.Physiol., 1973;62:37 PMID: 4541340
Alreja and Aghajanian QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons. Brain Res., 1994;639:320 PMID: 8205485
Perkins and Wong Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells. J.Neurophysiol., 1995;73:911 PMID: 7760149