R 268712

Name: R 268712
Brand: Tocris Bioscience
SKU: 5288
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5288

(1)

Citations (4)

COA / SDS

Potent and selective inhibitor of TGF-βRI

Key Product Details

Chemical Name:	4-[2-Fluoro-5-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]phenyl]-1H-pyrazole-1-ethanol
Purity:	≥98%

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Technical Data
Citations / Reviews (1)

Biological Activity for R 268712

R 268712 is a potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC₅₀ = 2.5 nM). Exhibits ~5000-fold selectivity over p38 MAPK. Suppresses development of renal fibrosis in a unilateral ureteral obstruction model. Also reduces proteinuria, glomerulosclerosis and improves renal function in an anti-Thy1 glomerulonephritis model. Orally bioavailable.

Technical Data for R 268712

Formula	C₂₀H₁₈FN₅O
Storage	Store at -20°C
Purity	≥98%
CAS Number	879487-87-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for R 268712

Solubility

Soluble Soluble to 100 mM in DMSO and to 50 mM in ethanol

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References for R 268712

References are publications that support the biological activity of the product.

Terashima et al. R-268712, an orally active transforming growth factor-β type I receptor inhibitor, prevents glomerular sclerosis in a Thy1 nephritis model. Eur.J.Pharmacol., 2014;734:60 PMID: 24726873

R 268712

Tocris Bioscience, part of Bio-Techne | Catalog # 5288

Key Product Details

Biological Activity for R 268712

Technical Data for R 268712

Solubility for R 268712

Dilution Calculator

Reconstitution Calculator

References for R 268712

Product Documents for R 268712

COA

Certificate of Analysis

SDS

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