(R)-(-)-Apomorphine hydrochloride

Name: ( R )-(-)-Apomorphine hydrochloride
Brand: Tocris Bioscience
SKU: 2073

Tocris Bioscience, part of Bio-Techne | Catalog # 2073

Citations (15)

COA / SDS

Dopamine agonist; non-subtype-selective

Key Product Details

Description:	Dopamine agonist; non-subtype-selective
Chemical Name:	(R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	303.79

View Full Technical Details for (R)-(-)-Apomorphine hydrochloride

Technical Data
Citations

Biological Activity for (R)-(-)-Apomorphine hydrochloride

(R)-(-)-Apomorphine hydrochloride is a prototypical dopamine agonist (pK_i values are 6.43, 7.08, 7.59, 8.36 and 7.83 for human recombinant D₁, D_2L, D₃, D₄ and D₅ receptors respectively). Produces biphasic effects on locomotor activity, and displays anti-Parkinsonian and neuroprotective actions following systemic administration in vivo.

Technical Data for (R)-(-)-Apomorphine hydrochloride

M. Wt	303.79
Formula	C₁₇H₁₇NO₂.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	314-19-2
PubChem ID	9410
InChi Key	SKYZYDSNJIOXRL-BTQNPOSSSA-N
Smiles	OC1=C2C(C[C@]4([H])C3=C2C=CC=C3CCN4C)=CC=C1O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R)-(-)-Apomorphine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	13.37	50
	DMSO	30.38	100

Preparing Stock Solutions for (R)-(-)-Apomorphine hydrochloride

The following data is based on the product molecular weight 303.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.29 mL	16.46 mL	32.92 mL
5 mM	0.66 mL	3.29 mL	6.58 mL
10 mM	0.33 mL	1.65 mL	3.29 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

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References for (R)-(-)-Apomorphine hydrochloride

References are publications that support the biological activity of the product.

Grunblatt Apomorphine protects against MPTP-induced neurotoxicity in mice. Mov.Disord. 1999 PMID: 10435498
Millan Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J.Pharmacol.Exp.Ther. 2002 PMID: 12388666
Liu Low doses of apomor. suppress operant motor performance in rats. Pharmacol.Biochem.Behav. 1996 PMID: 8808141