(R)-(+)-Etomoxir sodium salt

Name: ( R )-(+)-Etomoxir sodium salt
Brand: Tocris Bioscience
SKU: 4539
Rating: 5 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4539

(3)

Citations (21)

COA / SDS

Carnitine palmitoyltransferase I (CPT1) inhibitor

Key Product Details

Description:	Carnitine palmitoyltransferase I (CPT1) inhibitor
Chemical Name:	(R)-(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	320.74

View Full Technical Details for (R)-(+)-Etomoxir sodium salt

Technical Data
Citations / Reviews (3)

Biological Activity for (R)-(+)-Etomoxir sodium salt

(R)-(+)-Etomoxir sodium salt is an inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β-oxidation in mitochondria. Shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.

Technical Data for (R)-(+)-Etomoxir sodium salt

M. Wt	320.74
Formula	C₁₅H₁₈ClNaO₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	828934-41-4
PubChem ID	57345784
InChi Key	RPACBEVZENYWOL-XFULWGLBSA-M
Smiles	[Na+].[O-]C(=O)[C@@]1(CCCCCCOC2=CC=C(Cl)C=C2)CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R)-(+)-Etomoxir sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	6.41	20
	DMSO	6.41	20 with gentle warming

Preparing Stock Solutions for (R)-(+)-Etomoxir sodium salt

The following data is based on the product molecular weight 320.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	15.59 mL	77.94 mL	155.89 mL
1 mM	3.12 mL	15.59 mL	31.18 mL
2 mM	1.56 mL	7.79 mL	15.59 mL
10 mM	0.31 mL	1.56 mL	3.12 mL

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Reconstitution Calculator

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References for (R)-(+)-Etomoxir sodium salt

References are publications that support the biological activity of the product.

Agius Stereospecificity of the inhibition of etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes. Biochem.Pharmacol. 1991 PMID: 1930298
Rupp Modification of subcellular organelles in pressure-overloaded heart by etomoxir, a carnitine palmitoyltransferase I inhibitor. FASEB J. 1992 PMID: 1531968
Xu Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J.Lipid Res. 2003 PMID: 12576524