(R)-MG 132

Name: ( R )-MG 132
Brand: Tocris Bioscience
SKU: 6033

Tocris Bioscience, part of Bio-Techne | Catalog # 6033

Citations (3)

COA / SDS

Potent 20S proteasome inhibitor

Key Product Details

Description:	Potent 20S proteasome inhibitor
Chemical Name:	N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide
Purity:	≥98% (HPLC)
Molecular Weight:	475.63

View Full Technical Details for (R)-MG 132

Technical Data
Citations

Biological Activity for (R)-MG 132

(R)-MG 132 is a potent 20S proteasome inhibitor (IC₅₀ = 0.22 nM). Exhibits cytostatic and cytotoxic effects in tumor cells in vitro.

Technical Data for (R)-MG 132

M. Wt	475.63
Formula	C₂₆H₄₁N₃O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1211877-36-9
PubChem ID	45103781
InChi Key	TZYWCYJVHRLUCT-ZRBLBEILSA-N
Smiles	CC(C[C@@H](C=O)NC([C@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(C)C)=O)CC(C)C)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R)-MG 132

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.56	100
	ethanol	9.51	20

Preparing Stock Solutions for (R)-MG 132

The following data is based on the product molecular weight 475.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.10 mL	10.51 mL	21.02 mL
5 mM	0.42 mL	2.10 mL	4.20 mL
10 mM	0.21 mL	1.05 mL	2.10 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for (R)-MG 132

References are publications that support the biological activity of the product.

Mroczkiewicz Studies of the synthesis of all stereoisomers of MG-132 proteasome inhibitors in the tumor targeting approach. J.Med.Chem. 2010 PMID: 20112914