RA 839

Name: RA 839
Brand: Tocris Bioscience
SKU: 5707

Tocris Bioscience, part of Bio-Techne | Catalog # 5707

Citations (8)

COA / SDS

Nrf2 activator; inhibits Nrf2/Keap1 interaction

Key Product Details

Description:	Nrf2 activator; inhibits Nrf2/Keap1 interaction
Chemical Name:	(3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	452.57

View Full Technical Details for RA 839

Technical Data
Citations

Biological Activity for RA 839

RA 839 is an Nrf2 activator; inhibits Nrf2/Keap1 interaction (K_d = 6 μM). Suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.

Compound Libraries for RA 839

RA 839 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for RA 839

M. Wt	452.57
Formula	C₂₅H₂₈N₂O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1832713-02-6
PubChem ID	91971266
InChi Key	BVYWIQHJXAEJOD-IBGZPJMESA-N
Smiles	CC1=C(C)C=C(C)C(C)=C1S(=O)(NC2=C(C=CC=C3)C3=C(N4C[C@@H](C(O)=O)CC4)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RA 839

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	45.26	100

Preparing Stock Solutions for RA 839

The following data is based on the product molecular weight 452.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.21 mL	11.05 mL	22.10 mL
5 mM	0.44 mL	2.21 mL	4.42 mL
10 mM	0.22 mL	1.10 mL	2.21 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for RA 839

References are publications that support the biological activity of the product.

Winkel Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. J.Biol.Chem. 2015 PMID: 26459563