Radicicol

Name: Radicicol
Brand: Tocris Bioscience
SKU: 1589

Tocris Bioscience, part of Bio-Techne | Catalog # 1589

Citations (15)

COA / SDS

Hsp90 inhibitor. Antifungal antibiotic

Key Product Details

Description:	Hsp90 inhibitor. Antifungal antibiotic
Chemical Name:	(1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	364.78

View Full Technical Details for Radicicol

Technical Data
Citations

Biological Activity for Radicicol

Radicicol is an antifungal antibiotic. Inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis.

Technical Data for Radicicol

M. Wt	364.78
Formula	C₁₈H₁₇ClO₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	12772-57-5
PubChem ID	6323491
InChi Key	WYZWZEOGROVVHK-GTMNPGAYSA-N
Smiles	O=C2/C=C/C=C\[C@@H](O3)[C@H]3C[C@@H](C)OC(C1=C(O)C=C(O)C(Cl)=C1C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Radicicol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	ethanol	3.65	10

Preparing Stock Solutions for Radicicol

The following data is based on the product molecular weight 364.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.41 mL	137.07 mL	274.14 mL
0.5 mM	5.48 mL	27.41 mL	54.83 mL
1 mM	2.74 mL	13.71 mL	27.41 mL
5 mM	0.55 mL	2.74 mL	5.48 mL

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References for Radicicol

References are publications that support the biological activity of the product.

Oikawa Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis. Eur.J.Pharmacol. 1993 PMID: 7694864
Schulte Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. Mol.Endocrinol. 1999 PMID: 10478836
Lee Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90. Mol.Cell.Endocrinol. 2002 PMID: 11911945