Reversan

Name: Reversan
Brand: Tocris Bioscience
SKU: 3722

Tocris Bioscience, part of Bio-Techne | Catalog # 3722

Citations (8)

COA / SDS

Selective MRP1 and P-gp inhibitor

Key Product Details

Chemical Name:	N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Purity:	≥95%

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Technical Data
Citations

Biological Activity for Reversan

Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin (Cat. No. 2252), vincristine (Cat. No. 1257) and etoposide (Cat. No. 1226) by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo. Does not sensitize MRP2, MRP3, MRP4 or MRP5 transporters to known substrates.

Technical Data for Reversan

Formula	C₂₆H₂₇N₅O₂
Storage	Store at -20°C
Purity	≥95%
CAS Number	313397-13-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Reversan

Solubility

Soluble Soluble to 25 mM in DMSO

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References for Reversan

References are publications that support the biological activity of the product.

Burkhart et al. Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Res., 2009;69:6573 PMID: 19654298

Reversan

Tocris Bioscience, part of Bio-Techne | Catalog # 3722

Key Product Details

Biological Activity for Reversan

Technical Data for Reversan

Solubility for Reversan

Dilution Calculator

Reconstitution Calculator

References for Reversan

Product Documents for Reversan

COA

Certificate of Analysis

SDS

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