RHC 80267

Name: RHC 80267
Brand: Tocris Bioscience
SKU: 1842

Tocris Bioscience, part of Bio-Techne | Catalog # 1842

Citations (11)

COA / SDS

Diacylglycerol lipase inhibitor

Key Product Details

Chemical Name:	O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioxime cyclohexanone
Purity:	≥95%
Molecular Weight:	394.51 kDa

View Full Technical Details for RHC 80267

Technical Data
Citations

Biological Activity for RHC 80267

RHC 80267 is an inhibitor of diacylglycerol lipase (IC₅₀ values are 1.1 and 4 μM in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A₂. Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC₅₀ = 4 μM).

Technical Data for RHC 80267

M. Wt	394.51 kDa
Formula	C₂₀H₃₄N₄O₄
Storage	Store at +4°C
Purity	≥95%
CAS Number	83654-05-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RHC 80267

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for RHC 80267

References are publications that support the biological activity of the product.

Ghisdal et al. The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase action. Eur.J.Pharmacol., 2005;517:97 PMID: 15958263
Sutherland and Amin Relative activities of rat and dog platelet phospholipase A₂ and diglyceride lipase. J.Biol.Chem., 1982;257:14006 PMID: 7142192
Suzuki et al. Effects of RHC-80267, an inhibitor of diacylglycerol lipase, on excitation of circular smooth muscle of the guinea-pig gastric antrum. J.Smooth Muscle Res., 2002;38:153 PMID: 12713022