Rhosin hydrochloride

Name: Rhosin hydrochloride
Brand: Tocris Bioscience
SKU: 5003

Tocris Bioscience, part of Bio-Techne | Catalog # 5003

Citations (22)

COA / SDS

Rho inhibitor

Key Product Details

Chemical Name:	D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride
Purity:	≥98%

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Technical Data
Citations

Biological Activity for Rhosin hydrochloride

Rhosin hydrochloride is a Rho GTPase inhibitor (K_d = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro. Also induces neurite outgrowth in synergy with NGF.

Technical Data for Rhosin hydrochloride

Formula	C₂₀H₁₈N₆O.HCl
Storage	Store at -20°C
Purity	≥98%
CAS Number	1281870-42-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rhosin hydrochloride

Solubility

Soluble Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO

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References for Rhosin hydrochloride

References are publications that support the biological activity of the product.

Y Okamoto, K Kitakaze, Y Takenouchi, S Yamamoto, H Ishimaru, K Tsuboi Sphingosine 1-phosphate receptor type 2 positively regulates interleukin (IL)-4/IL-13-induced STAT6 phosphorylation Cellular Signalling, 2021;88(0):110156. 2021 PMID: 34592416
Shang et al. Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proc.Natl.Acad.Sci.U.S.A., 2013;110:3155 PMID: 23382194
Shang et al. Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chem.Biol., 2012;19:699 PMID: 22726684

Rhosin hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5003

Key Product Details

Biological Activity for Rhosin hydrochloride

Technical Data for Rhosin hydrochloride

Solubility for Rhosin hydrochloride

Dilution Calculator

Reconstitution Calculator

References for Rhosin hydrochloride

Product Documents for Rhosin hydrochloride

COA

Certificate of Analysis

SDS

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