RHPS 4 methosulfate

Name: RHPS 4 methosulfate
Brand: Tocris Bioscience
SKU: 5311

Tocris Bioscience, part of Bio-Techne | Catalog # 5311

Citations (2)

COA / SDS

Telomerase inhibitor

Key Product Details

Description:	Telomerase inhibitor
Chemical Name:	3,11-Difluoro-6,8,13-trimethylquino[4,3,2-kl]acridinium methylsulfate
Purity:	≥98% (HPLC)
Molecular Weight:	458.48

View Full Technical Details for RHPS 4 methosulfate

Technical Data
Citations

Biological Activity for RHPS 4 methosulfate

RHPS 4 methosulfate is a telomerase inhibitor. Inhibits growth of medulloblastoma and glioblastoma cells in vitro. Induces telomere injury and apoptosis, and reduces growth in CG5 breast cancer cell xenografts in mice. Sensitizes radiation resistant glioblastoma cell lines to radiation.

Technical Data for RHPS 4 methosulfate

M. Wt	458.48
Formula	C₂₂H₁₇F₂N₂.CH₃O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	390362-78-4
PubChem ID	9804187
InChi Key	VRWGYMXWYZBBGF-UHFFFAOYSA-M
Smiles	C[N+]4=C2C3=C(C=C(C)C=C3C5=C4C=CC(F)=C5)N(C)C1=CC=C(F)C=C12.COS(=O)([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RHPS 4 methosulfate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	4.58	10 with gentle warming
	DMSO	9.17	20

Preparing Stock Solutions for RHPS 4 methosulfate

The following data is based on the product molecular weight 458.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.91 mL	54.53 mL	109.06 mL
1 mM	2.18 mL	10.91 mL	21.81 mL
2 mM	1.09 mL	5.45 mL	10.91 mL
10 mM	0.22 mL	1.09 mL	2.18 mL

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References for RHPS 4 methosulfate

References are publications that support the biological activity of the product.

Berardinelli The G-quadruplex-stabilising agent RHPS4 induces telomeric dysfunction and enhances radiosensitivity in glioblastoma cells. DNA Repair (Amst.) 2015 PMID: 25467559
Salvati Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J.Clin.Invest. 2007 PMID: 17932567
Phatak Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism. Br.J.Cancer 2007 PMID: 17406367
Lagah RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells. PLoS One 2014 PMID: 24454961