Ritanserin

Name: Ritanserin
Brand: Tocris Bioscience
SKU: 1955

Tocris Bioscience, part of Bio-Techne | Catalog # 1955

Citations (36)

COA / SDS

Potent 5-HT2 antagonist

Key Product Details

Description:	Potent 5-HT₂ antagonist
Chemical Name:	6-[2-[4-[Bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
Purity:	≥98% (HPLC)
Molecular Weight:	477.57

View Full Technical Details for Ritanserin

Technical Data
Citations

Biological Activity for Ritanserin

Ritanserin is a potent and long-acting 5-HT₂ receptor antagonist (K_i = 0.39 nM). Anxiolytic in vivo.

Compound Libraries for Ritanserin

Ritanserin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ritanserin

M. Wt	477.57
Formula	C₂₇H₂₅F₂N₃OS
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	87051-43-2
PubChem ID	5074
InChi Key	JUQLTPCYUFPYKE-UHFFFAOYSA-N
Smiles	O=C1N3C(SC=C3)=NC(C)=C1CCN4CC/C(CC4)=C(C5=CC=C(F)C=C5)/C2=CC=C(F)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ritanserin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	11.94	25
	DMSO	47.76	100

Preparing Stock Solutions for Ritanserin

The following data is based on the product molecular weight 477.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.47 mL	20.94 mL
5 mM	0.42 mL	2.09 mL	4.19 mL
10 mM	0.21 mL	1.05 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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Reconstitution Calculator

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References for Ritanserin

References are publications that support the biological activity of the product.

Leysen Receptor-binding properties in vitro and in vivo of ritanserin. Mol.Pharmacol. 1985 PMID: 2860558
Watanabe Syntheses and 5-HT₂ antagonist activity of bicyclic 1,2,4-triazol-3(2H)-one and 1,3,5-triazine-2,4(3H)-dione derivatives. J.Med.Chem. 1992 PMID: 1732528
Janssen Pharmacology of potent and selective S₂-serotonergic antagonists. J.Cardiovasc.Pharmacol. 1985 PMID: 2412048