RKI 1447 dihydrochloride

Name: RKI 1447 dihydrochloride
Brand: Tocris Bioscience
SKU: 5061

Tocris Bioscience, part of Bio-Techne | Catalog # 5061

Citations (2)

COA / SDS

Potent and selective ROCK inhibitor; antitumor

Key Product Details

Chemical Name:	N-[(3-Hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]urea dihydrochloride
Purity:	≥99%

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Technical Data
Citations

Biological Activity for RKI 1447 dihydrochloride

RKI 1447 dihydrochloride is a potent and selective ROCK inhibitor (IC₅₀ values are 6.2 and 14.5 nM for ROCK2 and ROCK1 respectively); suppresses phosphorylation of ROCK substrates MLC-2 and MYPT-1 in human cancer cells, but has no effect on the phosphorylation levels of Akt, MEK, and S6 kinase. Displays anti-invasive and antitumor activities in breast cancer cells. RKI 1447 dihydrochloride enhances the efficacy of BET inhibitors on the downregulation of N-Myc in vitro and in vivo.

Technical Data for RKI 1447 dihydrochloride

Formula	C₁₆H₁₄N₄O₂S.2HCl
Storage	Store at -20°C
Purity	≥99%
CAS Number	1782109-09-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RKI 1447 dihydrochloride

Solubility

Soluble Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO

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References for RKI 1447 dihydrochloride

References are publications that support the biological activity of the product.

Patel et al. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Res., 2012;72:5025 PMID: 22846914
Pireddu et al. Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2) Med.Chem.Comm., 2013;3:699 PMID: 23275831

RKI 1447 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5061

Key Product Details

Biological Activity for RKI 1447 dihydrochloride

Technical Data for RKI 1447 dihydrochloride

Solubility for RKI 1447 dihydrochloride

Dilution Calculator

Reconstitution Calculator

References for RKI 1447 dihydrochloride

Product Documents for RKI 1447 dihydrochloride

COA

Certificate of Analysis

SDS

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