Ro 1138452 hydrochloride

Name: Ro 1138452 hydrochloride
Brand: Tocris Bioscience
SKU: 4268

Tocris Bioscience, part of Bio-Techne | Catalog # 4268

Citations (1)

COA / SDS

Selective prostacyclin IP receptor antagonist

Discontinued Product

4268 has been discontinued. View all Prostanoid Receptor Antagonists products.

Key Product Details

Description:	Selective prostacyclin IP receptor antagonist
Chemical Name:	4,5-Dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-1H-imidazol-2-amine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	345.87

View Full Technical Details for Ro 1138452 hydrochloride

Technical Data
Citations

Biological Activity for Ro 1138452 hydrochloride

Ro 1138452 hydrochloride is a selective prostacyclin IP receptor antagonist (pK_i = 8.3). Exhibits no affinity at other prostanoid receptors (EP_1-4, FP and TP) in a radioligand binding assay. Demonstrates analgesic activity in rats. Orally bioavailable.

Compound Libraries for Ro 1138452 hydrochloride

Ro 1138452 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ro 1138452 hydrochloride

M. Wt	345.87
Formula	C₁₉H₂₃N₃O.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
PubChem ID	91826074
InChi Key	OYPSAMWVIBGRMV-UHFFFAOYSA-N
Smiles	CC(C)OC1=CC=C(CC2=CC=C(NC3=NCCN3)C=C2)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Ro 1138452 hydrochloride

References are publications that support the biological activity of the product.

Jones Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel and platelet preparations. Br.J.Pharmacol. 2006 PMID: 16880763
Bley RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br.J.Pharmacol. 2006 PMID: 16331286
Clark Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists. Bioorg.Med.Chem.Lett. 2004 PMID: 15013022