Ro 15-4513

Name: Ro 15-4513
Brand: Tocris Bioscience
SKU: 1997

Tocris Bioscience, part of Bio-Techne | Catalog # 1997

Citations (237)

COA / SDS

Benzodiazepine partial inverse agonist

Key Product Details

Description:	Benzodiazepine partial inverse agonist
Chemical Name:	8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	326.31

View Full Technical Details for Ro 15-4513

Technical Data
Citations

Biological Activity for Ro 15-4513

Ro 15-4513 is a high affinity benzodiazepine ligand. K_i values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α1-, α2-, α3- and α5-GABA_A receptors. Displays partial agonism at DI α4- and α6-GABA_A receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.

Technical Data for Ro 15-4513

M. Wt	326.31
Formula	C₁₅H₁₄N₆O₃
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	91917-65-6
PubChem ID	5081
InChi Key	CFSOJZTUTOQNIA-UHFFFAOYSA-N
Smiles	CCOC(=O)C1=C2CN(C)C(=O)C3=C(C=CC(=C3)N=[N+]=[N-])N2C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ro 15-4513

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	1.63	5
	DMSO	3.26	10

Preparing Stock Solutions for Ro 15-4513

The following data is based on the product molecular weight 326.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.65 mL	153.23 mL	306.46 mL
0.5 mM	6.13 mL	30.65 mL	61.29 mL
1 mM	3.06 mL	15.32 mL	30.65 mL
5 mM	0.61 mL	3.06 mL	6.13 mL

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References for Ro 15-4513

References are publications that support the biological activity of the product.

Wong and Skolnick High affinity ligands for 'D.pam-insensitive' benzodiazepine receptors. Eur.J.Pharmacol. 1992 PMID: 1311690
Knoflach Pharmacological modulation of the D.pam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2. Mol.Pharmacol. 1996 PMID: 8913357
Suzdak A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science 1986 PMID: 3022383