Ro 20-1724

Name: Ro 20-1724
Brand: Tocris Bioscience
SKU: 0415

Tocris Bioscience, part of Bio-Techne | Catalog # 0415

Citations (28)

COA / SDS

PDE4 inhibitor

Key Product Details

Chemical Name:	4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone
Purity:	≥99%
Molecular Weight:	278.35 kDa

View Full Technical Details for Ro 20-1724

Technical Data
Citations

Biological Activity for Ro 20-1724

Ro 20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC₅₀ = 2.0 μM).

Technical Data for Ro 20-1724

M. Wt	278.35 kDa
Formula	C₁₅H₂₂N₂O₃
Storage	Store at RT
Purity	≥99%
CAS Number	29925-17-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ro 20-1724

Solubility

Soluble Soluble to 100 mM in ethanol and to 100 mM in DMSO

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Ro 20-1724

References are publications that support the biological activity of the product.

Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach-Mansky R, Sacks D, Germain R, Kastner D, Chae J The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature, 2012;492(7427):123-7. 2012 PMID: 23143333
Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Ahluwalia and Nicholson et al. Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TiPS, 1991;12:19 PMID: 1848733
Soderling et al. Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc.Natl.Acad.Sci.U.S.A., 1998;95:8991 PMID: 9671792
Reeves et al. The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Biochem.J., 1987;241:535 PMID: 3036066