RO 5263397 hydrochloride

Name: RO 5263397 hydrochloride
Brand: Tocris Bioscience
SKU: 6833

Tocris Bioscience, part of Bio-Techne | Catalog # 6833

COA / SDS

Potent TA1 receptor agonist

Key Product Details

Description:	Potent TA₁ receptor agonist
Chemical Name:	(4S)-4-(3-Fluoro-2-methylphenyl)-4,5-dihydro-2-oxazolamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	230.67

View Full Technical Details for RO 5263397 hydrochloride

Technical Data
Citations

Biological Activity for RO 5263397 hydrochloride

RO 5263397 hydrochloride is a potent trace amine 1 (TA₁) receptor agonist (EC₅₀ values are 0.12, 35 and 17-85 nM for mouse, rat and human receptors, respectively). Increases wakefulness and reduces REM and NREM sleep duration in wild type mice. Inhibits spontaneous locomotor activity in dopamine transport (DAT) knockout mice.

Compound Libraries for RO 5263397 hydrochloride

RO 5263397 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for RO 5263397 hydrochloride

M. Wt	230.67
Formula	C₁₀H₁₁FN₂O.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
InChi Key	JFAYMXKBMDRFHY-SBSPUUFOSA-N
Smiles	CC1=C([C@H]2COC(N)=N2)C=CC=C1F.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RO 5263397 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.07	100
	water	23.07	100

Preparing Stock Solutions for RO 5263397 hydrochloride

The following data is based on the product molecular weight 230.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.34 mL	21.68 mL	43.35 mL
5 mM	0.87 mL	4.34 mL	8.67 mL
10 mM	0.43 mL	2.17 mL	4.34 mL
50 mM	0.09 mL	0.43 mL	0.87 mL

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References for RO 5263397 hydrochloride

References are publications that support the biological activity of the product.

Galley Discovery and characterization of 2-aminooxazolines as highly potent, selective, and orally active TAAR1 agonists. ACS.Med.Chem.Letts. 2015 PMID: 26985297
Schwartz Trace amine-associated receptor 1 regulates wakefulness and EEG spectral composition. Neuropsychopharmacology. 2017 PMID: 27658486
Espinoza Biochemical and functional characterization of the trace amine-associated receptor 1 (TAAR1) agonist RO5263397. Front.Pharmacol. 2018 PMID: 29977204