Ro 6842262

Name: Ro 6842262
Brand: Tocris Bioscience
SKU: 5913
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5913

(1)

Citations (3)

COA / SDS

Potent LPA1 antagonist

Key Product Details

Description:	Potent LPA₁ antagonist
Chemical Name:	1-[4'-[4-Methyl-5-[[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1'-biphenyl]-4-yl]cyclopropanecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	482.53

View Full Technical Details for Ro 6842262

Technical Data
Citations / Reviews (1)

Biological Activity for Ro 6842262

Ro 6842262 is a potent LPA₁ antagonist (IC₅₀ = 25 nM). Exhibits >1,200-fold selectivity for LPA₁ over LPA₃. Attenuates NHLF human lung fibroblast cell proliferation and contraction in vitro. Also reduces plasma histamine levels in mouse LPA-challenge model. Orally bioavailable.

Compound Libraries for Ro 6842262

Ro 6842262 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ro 6842262

M. Wt	482.53
Formula	C₂₈H₂₆N₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1396006-71-5
PubChem ID	71265339
InChi Key	PXQUHYSYFWQRMF-LJQANCHMSA-N
Smiles	CC1=C(NC(O[C@H](C)C2=CC=CC=C2)=O)N(C3=CC=C(C4=CC=C(C5(CC5)C(O)=O)C=C4)C=C3)N=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ro 6842262

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	48.25	100
	ethanol	9.65	20

Preparing Stock Solutions for Ro 6842262

The following data is based on the product molecular weight 482.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.07 mL	10.36 mL	20.72 mL
5 mM	0.41 mL	2.07 mL	4.14 mL
10 mM	0.21 mL	1.04 mL	2.07 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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References for Ro 6842262

References are publications that support the biological activity of the product.

Qian Discovery of highly selective and orally active lysophosphatidic acid receptor-1 antagonists with potent activity on human lung fibroblasts. J.Med.Chem. 2012 PMID: 22894757