Rosiglitazone

Name: Rosiglitazone
Brand: Tocris Bioscience
SKU: 5325
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5325

(1)

Citations (48)

COA / SDS

Potent and selective PPARγ agonist; antidiabetic agent

Key Product Details

Description:	Potent and selective PPARγ agonist; antidiabetic agent
Alternative Names:	BRL 49653
Chemical Name:	5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
Purity:	≥98% (HPLC)
Molecular Weight:	357.43

View Full Technical Details for Rosiglitazone

Technical Data
Citations / Reviews (1)

Biological Activity for Rosiglitazone

Rosiglitazone is a potent and selective PPARγ agonist (EC₅₀ = 60 nM); exhibits no activity at PPARα and PPARβ. Promotes differentiation of pluripotent C3H10T1/2 stem cells into adipocytes. Also promotes differentiation of urothelial organoids in combination with Erlotinib (Cat. No. 7194). Exhibits antihyperglycemic activity in diabetic ob/ob mouse model. Antidiabetic agent.

Compound Libraries for Rosiglitazone

Rosiglitazone is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Rosiglitazone

M. Wt	357.43
Formula	C₁₈H₁₉N₃O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	122320-73-4
PubChem ID	77999
InChi Key	YASAKCUCGLMORW-UHFFFAOYSA-N
Smiles	CN(CCOC1=CC=C(CC2SC(NC2=O)=O)C=C1)C3=CC=CC=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rosiglitazone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.74	100

Preparing Stock Solutions for Rosiglitazone

The following data is based on the product molecular weight 357.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.80 mL	13.99 mL	27.98 mL
5 mM	0.56 mL	2.80 mL	5.60 mL
10 mM	0.28 mL	1.40 mL	2.80 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for Rosiglitazone

References are publications that support the biological activity of the product.

Willson The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 1996 PMID: 8576907
Santos Urothelial organoids originating from Cd49f^high mouse stem cells display Notch-dependent differentiation capacity. Nat.Commun. 2019 PMID: 31562298
Lehmann An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J.Biol.Chem. 1995 PMID: 7768881