Rostafuroxin

Name: Rostafuroxin
Brand: Tocris Bioscience
SKU: 5315

Tocris Bioscience, part of Bio-Techne | Catalog # 5315

COA / SDS

Na+/K+ ATPase modulator; antihypertensive agent

Key Product Details

Description:	Na⁺/K⁺ ATPase modulator; antihypertensive agent
Alternative Names:	PST 2238
Chemical Name:	3β,5β,14β)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol
Purity:	≥98% (HPLC)
Molecular Weight:	374.51

View Full Technical Details for Rostafuroxin

Technical Data
Citations

Biological Activity for Rostafuroxin

Rostafuroxin is a Na⁺/K⁺ ATPase modulator. Inhibits the Normalizes renal Na⁺/K⁺ ATPase pump function in mutant adducin- and endogenous ouabain-dependent forms of hypertension. Reduces blood pressure in Milan hypertensive rats. Controls mania-like behaviors in Myshkin mice having a Na⁺/K⁺ ATPase α3 subunit mutation. Antagonizes the effects of Ouabain (Cat.No. 1076) on myogenic tone and Ca²⁺ signaling in rat hippocampal neurons.

Technical Data for Rostafuroxin

M. Wt	374.51
Formula	C₂₃H₃₄O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	156722-18-8
PubChem ID	153976
InChi Key	AEAPORIZZWBIEX-DTBDINHYSA-N
Smiles	O[C@]4(C5=COC=C5)CC[C@]3(O)[C@]2([H])CC[C@]1([H])C[C@@H](O)CC[C@@](C)1[C@]([H])2CC[C@@]34C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rostafuroxin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.45	100
	ethanol	37.45	100

Preparing Stock Solutions for Rostafuroxin

The following data is based on the product molecular weight 374.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.67 mL	13.35 mL	26.70 mL
5 mM	0.53 mL	2.67 mL	5.34 mL
10 mM	0.27 mL	1.34 mL	2.67 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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References for Rostafuroxin

References are publications that support the biological activity of the product.

Song Ouabain-digoxin antagonism in rat arteries and neurones. J.Physiol. 2014 PMID: 24344167
Kirshenbaum Mania-like behavior induced by genetic dysfunction of the neuron-specific Na⁺,K⁺-ATPase α3 sodium pump. Proc.Natl.Acad.Sci.U.S.A. 2011 PMID: 22025725
Ferrari Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension. Biochim Biophys Acta. 2010 PMID: 20083196
Ferrari Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension. Am.J.Physiol.Regul.Integr.Comp.Physiol. 2006 PMID: 16467500