Rosuvastatin calcium

Name: Rosuvastatin calcium
Brand: Tocris Bioscience
SKU: 6343

Tocris Bioscience, part of Bio-Techne | Catalog # 6343

Citations (1)

COA / SDS

Potent HMG-CoA reductase inhibitor

Key Product Details

Description:	Potent HMG-CoA reductase inhibitor
Chemical Name:	(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl])-3,5-dihydroxyhept-6-enoic acid hemicalcium salt
Purity:	≥99% (HPLC)
Molecular Weight:	500.57

View Full Technical Details for Rosuvastatin calcium

Technical Data
Citations

Biological Activity for Rosuvastatin calcium

Rosuvastatin calcium is a potent HMG-CoA reductase inhibitor (IC₅₀ = 5.4 nM). Inhibits cholesterol synthesis in rat hepatocytes in vitro and in vivo. Reduces plasma LDL cholesterol levels. Enhances lentiviral transduction of natural killer cells. Orally bioavailable.

Compound Libraries for Rosuvastatin calcium

Rosuvastatin calcium is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Rosuvastatin calcium

M. Wt	500.57
Formula	C₂₂H₂₇FN₃O₆S.½Ca
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	147098-20-2
PubChem ID	5282455
InChi Key	LALFOYNTGMUKGG-BGRFNVSISA-L
Smiles	CC(C1=C(C(C2=CC=C(F)C=C2)=NC(N(S(C)(=O)=O)C)=N1)/C=C/[C@@H](O)C[C@@H](O)CC(O[Ca]OC(C[C@H](O)C[C@H](O)/C=C/C(C(C3=CC=C(F)C=C3)=NC(N(S(C)(=O)=O)C)=N4)=C4C(C)C)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rosuvastatin calcium

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	50.06	100

Preparing Stock Solutions for Rosuvastatin calcium

The following data is based on the product molecular weight 500.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.00 mL	9.99 mL	19.98 mL
5 mM	0.40 mL	2.00 mL	4.00 mL
10 mM	0.20 mL	1.00 mL	2.00 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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Reconstitution Calculator

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References for Rosuvastatin calcium

References are publications that support the biological activity of the product.

Gong Rosuvastatin enhances VSV-G lentiviral transduction of NK cells via upregulation of the low-density lipoprotein receptor. Mol.Ther.Methods Clin.Dev. 2020 PMID: 32300610
McTaggart Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Am.J.Cardiol. 2001 PMID: 11256847