Rottlerin

Name: Rottlerin
Brand: Tocris Bioscience
SKU: 1610

Tocris Bioscience, part of Bio-Techne | Catalog # 1610

Citations (45)

COA / SDS

Reported PKCδ inhibitor

Key Product Details

Description:	Reported PKCδ inhibitor
Chemical Name:	3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
Purity:	≥95% (HPLC)
Molecular Weight:	516.55

View Full Technical Details for Rottlerin

Technical Data
Citations

Biological Activity for Rottlerin

Originally reported to inhibit PKC isoforms. Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC₅₀ values are 1.9 and 5 μM respectively). Also shown to act as a direct mitochondrial uncoupler. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways.

Technical Data for Rottlerin

M. Wt	516.55
Formula	C₃₀H₂₈O₈
Storage	Store at +4°C
Purity	≥95% (HPLC)
CAS Number	82-08-6
PubChem ID	5281847
InChi Key	DEZFNHCVIZBHBI-ZHACJKMWSA-N
Smiles	CC(=O)C1=C(O)C(CC2=C(O)C(C(=O)\C=C\C3=CC=CC=C3)=C3OC(C)(C)C=CC3=C2O)=C(O)C(C)=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rottlerin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.33	20

Preparing Stock Solutions for Rottlerin

The following data is based on the product molecular weight 516.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.68 mL	48.40 mL	96.80 mL
1 mM	1.94 mL	9.68 mL	19.36 mL
2 mM	0.97 mL	4.84 mL	9.68 mL
10 mM	0.19 mL	0.97 mL	1.94 mL

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References for Rottlerin

References are publications that support the biological activity of the product.

Balgi Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 2009 PMID: 19771169
Gschwendt Rottlerin, a novel protein kinase inhibitor. Biochem.Biophys.Res.Commun. 1994 PMID: 8123051
Zhang Neuroprotective effect of protein kinase Cδ inhibitor rottlerin in cell culture and animal models of Parkinson's disease. J.Pharmacol.Exp.Ther. 2007 PMID: 17565007
Davies Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 2000 PMID: 10998351