Ryanodine

Name: Ryanodine
Brand: Tocris Bioscience
SKU: 1329

Tocris Bioscience, part of Bio-Techne | Catalog # 1329

Citations (223)

COA / SDS

Ca2+ release inhibitor

Key Product Details

Chemical Name:	1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester
Purity:	≥98%
Molecular Weight:	493.55 kDa

View Full Technical Details for Ryanodine

Technical Data
Citations

Biological Activity for Ryanodine

Ryanodine is a potent inhibitor of Ca²⁺ release from sarcoplasmic reticulum (IC₅₀ values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).

Technical Data for Ryanodine

M. Wt	493.55 kDa
Formula	C₂₅H₃₅NO₉
Storage	Desiccate at -20°C
Purity	≥98%
CAS Number	15662-33-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ryanodine

Solubility

Soluble Soluble to 10 mM in ethanol and to 25 mM in DMSO

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References for Ryanodine

References are publications that support the biological activity of the product.

Bianchi Conformation state of the ryanodine receptor and functional effects of ryanodine on skeletal muscle. Biochem.Pharmacol., 1997;53:909 PMID: 9174102
Sutko et al. Ryanodine: a modifier of sarcoplasmic reticulum calcium release in striated muscle. Fed.Proc., 1985;44:2984 PMID: 2415406
Sutko et al. The pharmacology of ryanodine and related compounds. Pharmacol.Rev., 1997;49:53 PMID: 9085309