S 2101

Name: S 2101
Brand: Tocris Bioscience
SKU: 5714

Tocris Bioscience, part of Bio-Techne | Catalog # 5714

Citations (2)

COA / SDS

LSD1 inhibitor

Key Product Details

Description:	LSD1 inhibitor
Chemical Name:	(1R,2S)-rel-2-[3,5-Difluoro-2-(phenylmethoxy)phenyl]cycloprpanamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	311.75

View Full Technical Details for S 2101

Technical Data
Citations

Biological Activity for S 2101

S 2101 is a LSD1 inhibitor (IC₅₀ = 990 nM; K_i = 610 nM). Exhibits selectivity for LSD1 over MAO-B and MAO-A (K_i values are 17 and 110 μM, respectively).

Technical Data for S 2101

M. Wt	311.75
Formula	C₁₆H₁₅F₂NO.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1239262-36-2
PubChem ID	121513887
InChi Key	CTSUZAFTJVLOIX-SBKWZQTDSA-N
Smiles	FC1=CC([C@@H]2C[C@H]2N)=C(OCC3=CC=CC=C3)C(F)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for S 2101

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	15.59	50
	DMSO	31.18	100

Preparing Stock Solutions for S 2101

The following data is based on the product molecular weight 311.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.21 mL	16.04 mL	32.08 mL
5 mM	0.64 mL	3.21 mL	6.42 mL
10 mM	0.32 mL	1.60 mL	3.21 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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Reconstitution Calculator

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References for S 2101

References are publications that support the biological activity of the product.

Mimasu Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1. Biochemistry 2010 PMID: 20568732