(S)-3,5-DHPG

Name: ( S )-3,5-DHPG
Brand: Tocris Bioscience
SKU: 0805
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0805

(2)

Citations (82)

COA / SDS

Selective group I mGlu agonist; active enantiomer of 3,5-DHPG (Cat. No. 0342)

Key Product Details

Description:	Selective group I mGlu agonist; active enantiomer of 3,5-DHPG (Cat. No. 0342)
Chemical Name:	(S)-3,5-Dihydroxyphenylglycine
Purity:	≥98% (HPLC)
Molecular Weight:	183.16

View Full Technical Details for (S)-3,5-DHPG

Technical Data
Citations / Reviews (2)

Biological Activity for (S)-3,5-DHPG

(S)-3,5-DHPG is a selective group I mGlu receptor agonist. (S)-3,5-DHPG regulates the expression of microRNAs in mouse cerebral cortex in vivo. (S)-3,5-DHPG induces a profound depression of synaptic dopamine release in mouse cortico-striatal cells in vitro, and anxiety-like behavior in vivo in mice.

Racemate also available.

Technical Data for (S)-3,5-DHPG

M. Wt	183.16
Formula	C₈H₉NO₄
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	162870-29-3
PubChem ID	443586
InChi Key	HOOWCUZPEFNHDT-ZETCQYMHSA-N
Smiles	OC1=CC([C@]([H])(N)C(O)=O)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-3,5-DHPG

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	9.16	50

Preparing Stock Solutions for (S)-3,5-DHPG

The following data is based on the product molecular weight 183.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	10.92 mL	54.60 mL	109.19 mL
2.5 mM	2.18 mL	10.92 mL	21.84 mL
5 mM	1.09 mL	5.46 mL	10.92 mL
25 mM	0.22 mL	1.09 mL	2.18 mL

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Reconstitution Calculator

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References for (S)-3,5-DHPG

References are publications that support the biological activity of the product.

Mercuri Long-term depression of striatal DA release induced by mGluRs via sustained hyperactivity of local cholinergic interneurons. Front Cell Neurosci. 2021 PMID: 34924961
Lusardi Effect of (S)-3,5-DHPG on microRNA expression in mouse brain. Exp.Neurol. 2012 PMID: 22309833
Baker Enzymatic resolution and pharmacological activity of the enantiomers of 3,5-dihydroxyphenylglycine, a metabotropic glutamate receptor agonist. Bioorg.Med.Chem.Lett.
Wisniewski and Car (S)-3,5-DHPG: a review. CNS Drug Rev. 2002 PMID: 12070529
Sekiyama Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 1996 PMID: 8730745
Schoepp 3,5-Dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus. J.Neurochem. 1994 PMID: 8035201