(S)-4-Carboxyphenylglycine

Name: ( S )-4-Carboxyphenylglycine
Brand: Tocris Bioscience
SKU: 0323
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0323

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Citations (41)

COA / SDS

Competitive group I mGlu antagonist; also weak group II agonist

Key Product Details

Description:	Competitive group I mGlu antagonist; also weak group II agonist
Alternative Names:	(S)-4CPG
Purity:	≥99% (HPLC)
Molecular Weight:	195.17

View Full Technical Details for (S)-4-Carboxyphenylglycine

Technical Data
Citations / Reviews (1)

Biological Activity for (S)-4-Carboxyphenylglycine

(S)-4-Carboxyphenylglycine is a competitive group I metabotropic glutamate receptor antagonist, with selectivity for mGlu_1a/1a over mGlu_5a/5b.

Technical Data for (S)-4-Carboxyphenylglycine

M. Wt	195.17
Formula	C₉H₉NO₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	134052-73-6
PubChem ID	5311459
InChi Key	VTMJKPGFERYGJF-ZETCQYMHSA-N
Smiles	[H][C@@](N)(C(O)=O)C1=CC=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-4-Carboxyphenylglycine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH	19.52	100 with gentle warming

Preparing Stock Solutions for (S)-4-Carboxyphenylglycine

The following data is based on the product molecular weight 195.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.12 mL	25.62 mL	51.24 mL
5 mM	1.02 mL	5.12 mL	10.25 mL
10 mM	0.51 mL	2.56 mL	5.12 mL
50 mM	0.10 mL	0.51 mL	1.02 mL

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Reconstitution Calculator

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References for (S)-4-Carboxyphenylglycine

References are publications that support the biological activity of the product.

Eaton Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG). Eur.J.Pharmacol. 1993 PMID: 8381746
Brabet Phenylglycine derivatives discriminate between mGluR1-and mGluR5-mediated responses. Neuropharmacology 1995 PMID: 8532171
Doherty Antagonist activity of α-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells. Br.J.Pharmacol. 1999 PMID: 10051137
Birse Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system. Neuroscience 1993 PMID: 7680790