SAHM1

Name: SAHM1
Brand: Tocris Bioscience
SKU: 6477

Tocris Bioscience, part of Bio-Techne | Catalog # 6477

COA / SDS

Notch pathway inhibitor; prevents Notch complex assembly

Key Product Details

Description:	Notch pathway inhibitor; prevents Notch complex assembly
Purity:	≥95% (HPLC)
Molecular Weight:	2196.58

View Full Technical Details for SAHM1

Technical Data
Citations

Biological Activity for SAHM1

SAHM1 is a notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.

Technical Data for SAHM1

M. Wt	2196.58
Formula	C₉₄H₁₆₂N₃₆O₂₃S
Single Letter Sequence	AERLRRRIXLCRXHHST (Modifications: Ala-1 = N-terminal Ac & β-Ala, X = (S)-2-(4-pentenyl)alanine, X-9 and X-13 stapled together with a double bond)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2050906-89-1
PubChem ID	137919859
InChi Key	ADWKVIAAKDSBNE-VHQDTIAVSA-N
Smiles	[H]N([C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)[C@]1(C)CCC\C=C/CCC[C@](C)(NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(C)=O)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SAHM1

Solubility

Soluble to 1mg/ml in water

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References for SAHM1

References are publications that support the biological activity of the product.

Bagheri Notch pathway is active during osteogenic differentiation of human bone marrow mesenchymal stem cells induced by pulsed electromagnetic fields. J.Tissue Eng.Regen.Med. 2018 PMID: 28482141
KleinJan The Notch pathway inhibitor stapled a-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma. J.Allergy Clin.Immunol. 2018 PMID: 29111218
Ashley Notch signaling promotes osteoclast maturation and resorptive activity. J Cell Biochem 2015 PMID: 25914241