SAK 3

Name: SAK 3
Brand: Tocris Bioscience
SKU: 6239

Tocris Bioscience, part of Bio-Techne | Catalog # 6239

Citations (2)

COA / SDS

Potent CaV3.1 and 3.3 activator; orally bioavailable

Key Product Details

Description:	Potent Ca_V3.1 and 3.3 activator; orally bioavailable
Chemical Name:	Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate
Purity:	≥98% (HPLC)
Molecular Weight:	369.41

View Full Technical Details for SAK 3

Technical Data
Citations

Biological Activity for SAK 3

SAK 3 is a potent Ca_V3.1 and Ca_V3.3 activator. Enhances Ca_V3.1 and Ca_V3.3, but not Ca_V3.2 activity at concentrations of 0.01 - 10 M in neuro2A cells in vitro. Elevates ACh levels in hippocampus. Rescues impaired memory-related behaviors, promotes adult neurogenesis and displays antidepressant-like effects in OBX mice. Orally bioavailable.

Compound Libraries for SAK 3

SAK 3 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SAK 3

M. Wt	369.41
Formula	C₂₀H₂₃N₃O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1256269-87-0
PubChem ID	71655974
InChi Key	WZHBYTVHUFURPY-UHFFFAOYSA-N
Smiles	O=C(C1=C(C2(N3C=CC=C(C3=NC2=O)C)CC1=O)N4CCCCC4)OCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SAK 3

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.94	100
	1eq. HCl	36.94	100

Preparing Stock Solutions for SAK 3

The following data is based on the product molecular weight 369.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.71 mL	13.54 mL	27.07 mL
5 mM	0.54 mL	2.71 mL	5.41 mL
10 mM	0.27 mL	1.35 mL	2.71 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for SAK 3

References are publications that support the biological activity of the product.

Xu T-type calcium channel enhancer SAK3 produces anti-depressant-like effects by promoting adult hippocampal neurogenesis in olfactory bulbectomized mice. J.Pharmacol.Sci. 2018 PMID: 30196018
Yabuki Pharmacological properties of SAK3, a novel T-type voltage-gated Ca²⁺ channel enhancer. Neuropharmacology 2017 PMID: 28093211