Salvinorin A

Name: Salvinorin A
Brand: Tocris Bioscience
SKU: 2134

Tocris Bioscience, part of Bio-Techne | Catalog # 2134

Citations (1)

COA / SDS

Highly potent and selective κ agonist

Discontinued Product

2134 has been discontinued. View all Kappa Opioid Receptor Agonists products.

Key Product Details

Description:	Highly potent and selective κ agonist
Alternative Names:	Divinorin A
Chemical Name:	(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	432.47

View Full Technical Details for Salvinorin A

Technical Data
Citations

Biological Activity for Salvinorin A

Salvinorin A is a potent naturally occuring non-nitrogenous κ-opioid selective agonist that displays high affinity at both native (K_i = 4.3 nM) and cloned (K_i = 16 nM) κ-opioid receptors. Also exhibits allosteric modulation of μ-opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties..

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Salvinorin A is reviewed on the chemical probes website.

Technical Data for Salvinorin A

M. Wt	432.47
Formula	C₂₃H₂₈O₈
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	83729-01-5
PubChem ID	128563
InChi Key	OBSYBRPAKCASQB-AGQYDFLVSA-N
Smiles	O=C3[C@]2([H])CC[C@@]([C@]([H])1[C@](C)2C[C@@H]([C@]4=COC=C4)O3)(C)[C@H]([C@@](OC)=O)C[C@H](OC(C)=O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Salvinorin A

References are publications that support the biological activity of the product.

Roth Salvinorin A: a potent naturally occuring nonnitrogenous κ opioid selective agonist. Proc.Natl.Acad.Sci.USA
Scheffler and Roth Salvinorin A: the 'magic mint' hallucinogen finds a molecular target in the kappa opioid receptor. TiPS.
Rothman Salvinorin A: allosteric interactions at the μ-opioid receptor. J.Pharmacol.Exp.Ther. 2007 PMID: 17060492