Salvinorin B

Name: Salvinorin B
Brand: Tocris Bioscience
SKU: 5611
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5611

(1)

Citations (9)

COA / SDS

Activator of κ-opioid DREADD (KORD)

Key Product Details

Description:	Activator of κ-opioid DREADD (KORD)
Chemical Name:	(2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	390.43

View Full Technical Details for Salvinorin B

Technical Data
Citations / Reviews (1)

Biological Activity for Salvinorin B

Salvinorin B is a potent and selective κ-opioid DREADD (KORD) activator (EC₅₀ = 11.8 nM). Selective for KORD over endogenous κ opioid receptor and a range of other related targets. Exhibits no analgesic or ataxic effects in wild type mice. Induces neuronal hyperpolarization, and modifies locomotor activity and feeding behavior in KORD-expressing mouse models. Brain penetrant. Metabolite of salvinorin A.

Technical Data for Salvinorin B

M. Wt	390.43
Formula	C₂₁H₂₆O₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	92545-30-7
PubChem ID	11440685
InChi Key	BLTMVAIOAAGYAR-CEFSSPBYSA-N
Smiles	O=C3[C@]2([H])CC[C@@]([C@]([H])1[C@](C)2C[C@@H]([C@]4=COC=C4)O3)(C)[C@H]([C@@](OC)=O)C[C@H](O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Salvinorin B

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.81	20

Preparing Stock Solutions for Salvinorin B

The following data is based on the product molecular weight 390.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.81 mL	64.03 mL	128.06 mL
1 mM	2.56 mL	12.81 mL	25.61 mL
2 mM	1.28 mL	6.40 mL	12.81 mL
10 mM	0.26 mL	1.28 mL	2.56 mL

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References for Salvinorin B

References are publications that support the biological activity of the product.

Ansonoff Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of κ-opioid receptor-1 knockout mice. J.Pharmacol.Exp.Ther. 2006 PMID: 16672569
Vardy A new DREADD facilitates the multiplexed chemogenetic interrogation of behavior. Neuron 2015 PMID: 25937170