[Sar⁹,Met(O₂)¹¹]-Substance P

Name: [Sar 9 ,Met(O 2 ) 11 ]-Substance P
Brand: Tocris Bioscience
SKU: 1178

Tocris Bioscience, part of Bio-Techne | Catalog # 1178

Citations (9)

COA / SDS

Potent and selective NK1 agonist

Key Product Details

Description:	Potent and selective NK₁ agonist
Purity:	≥95% (HPLC)
Molecular Weight:	1393.68

View Full Technical Details for [Sar⁹,Met(O₂)¹¹]-Substance P

Technical Data
Citations

Biological Activity

[Sar⁹,Met(O₂)¹¹]-Substance P is a potent selective NK₁ tachykinin receptor agonist.

Technical Data

M. Wt	1393.68
Formula	C₆₄H₁₀₀N₁₈O₁₅S
Single Letter Sequence	RPKPQQFFXLM (Modifications: X = Sar, Met-11 = Met(O₂) & C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	110880-55-2
PubChem ID	163829
InChi Key	OUPXSLGGCPUZJJ-SARDKLJWSA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N(C)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

Soluble to 1mg/ml in water

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References

References are publications that support the biological activity of the product.

Tousignant ¹²⁵I-BH[Sar⁹,Met(O₂)¹¹]-SP, a new selective ligand for the NK-1 receptor in the central nervous system. Brain Res. 1990 PMID: 1705465
King Profile of neuronal excitation following selective activation of the neurokinin-1 receptor in rat deep dorsal horn in vitro. Brain Res. 1997 PMID: 9365015
Li and Zhao Small sensory neurons in the rat dorsal root ganglia express functional NK-1 tachykinin receptor. Eur.J.Neurosci. 1998 PMID: 9749783
Cellier Characterisation of central and peripheral effects of septide with the use of five tachykinin NK₁ receptor antagonists in the rat. Br.J.Pharmacol. 1999 PMID: 10401563

[Sar⁹,Met(O₂)¹¹]-Substance P

Tocris Bioscience, part of Bio-Techne | Catalog # 1178

Key Product Details

Biological Activity

Technical Data

Solubility

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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[Sar9,Met(O2)11]-Substance P

Tocris Bioscience, part of Bio-Techne | Catalog # 1178

Key Product Details

Biological Activity

Technical Data

Solubility

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

[Sar⁹,Met(O₂)¹¹]-Substance P