SB 206553 hydrochloride

Name: SB 206553 hydrochloride
Brand: Tocris Bioscience
SKU: 1661
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1661

(1)

Citations (6)

COA / SDS

Potent and selective 5-HT2B and 5-HT2C antagonist; orally active

Key Product Details

Description:	Potent and selective 5-HT_2B and 5-HT_2C antagonist; orally active
Chemical Name:	3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']dipyrrole-1(2H)-carboxamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	328.8

View Full Technical Details for SB 206553 hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for SB 206553 hydrochloride

SB 206553 hydrochloride is a potent and selective 5-HT_2B/5-HT_2C receptor antagonist (rat 5-HT_2B pA₂ = 8.89, human 5-HT_2C pK_i = 7.92). Displays > 80-fold selectivity over all other 5-HT receptor subtypes and a variety of other receptors (pK_i < 6). Centrally active following oral administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries for SB 206553 hydrochloride

SB 206553 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SB 206553 hydrochloride

M. Wt	328.8
Formula	C₁₇H₁₆N₄O.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1197334-04-5
PubChem ID	11957707
InChi Key	VGEMBOFBPSNOIO-UHFFFAOYSA-N
Smiles	Cl.CN1C=CC2=CC3=C(CCN3C(=O)NC3=CC=CN=C3)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 206553 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.88	100

Preparing Stock Solutions for SB 206553 hydrochloride

The following data is based on the product molecular weight 328.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.04 mL	15.21 mL	30.41 mL
5 mM	0.61 mL	3.04 mL	6.08 mL
10 mM	0.30 mL	1.52 mL	3.04 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

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References for SB 206553 hydrochloride

References are publications that support the biological activity of the product.

Kennett In vitro and in vivo profile of SB 206553, a potent 5-HT_2C/5-HT_2B receptor antagonist with anxiolytic-like properties. Br.J.Pharmacol. 1996 PMID: 8821530
Porras 5-HT_2A and 5-HT_2C/2B receptor subtypes modulate DA release induced in vivo by amphetamine and mor. in both the rat nucleus accumbens and striatum. Neuropsychopharmacology 2002 PMID: 11850146
Forbes 5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT_2C/5-HT_2B receptor antagonist with improved affinity, selectivity and oral activity. J.Med.Chem. 1995 PMID: 7629791