SB 24011

Name: SB 24011
Brand: Tocris Bioscience
SKU: 8010

Tocris Bioscience, part of Bio-Techne | Catalog # 8010

COA / SDS

Inhibitor of STING-TRIM29 interaction; increases cellular STING levels

Key Product Details

Description:	Inhibitor of STING-TRIM29 interaction; increases cellular STING levels
Chemical Name:	4-[(2R)-3,4-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]-2-(1-methylethyl)-3-oxo-1(2H)-pyrazinyl]-3-nitro-N-[[(2S)-tetrahydro-2-furanyl]methyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	614.7

View Full Technical Details for SB 24011

Technical Data
Citations

Biological Activity for SB 24011

SB 24011 is an inhibitor of STING-TRIM29 interaction (IC₅₀ = 3.85 μM in vitro). SB 24011 binds to STING and inhibits TRIM29-E3 ligase interaction to increase cellular STING levels. In syngeneic mouse models, SB 24011 dose-dependently reduces CT26 and B16F10 tumor volumes when co-admistered with cGAMP.

Technical Data for SB 24011

M. Wt	614.7
Formula	C₃₄H₃₈N₄O₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1497415-41-4
PubChem ID	171038176
InChi Key	UZVHJOMTRTYDKL-BHDXBOSCSA-N
Smiles	CC([C@H]1N(C2=C(C=C(C=C2)C(NC[C@@H]3CCCO3)=O)[N+]([O-])=O)C=C(N(C1=O)CC4=CC=C(C=C4)O)CC5=CC=C(C=C5)OC)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 24011

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	61.47	100

Preparing Stock Solutions for SB 24011

The following data is based on the product molecular weight 614.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.63 mL	8.13 mL	16.27 mL
5 mM	0.33 mL	1.63 mL	3.25 mL
10 mM	0.16 mL	0.81 mL	1.63 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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References for SB 24011

References are publications that support the biological activity of the product.

Cho Targeted protein upregulation of STING for boosting the efficacy of immunotherapy. Angew.Chem.Int.Ed.Engl. 2023 PMID: 36827625