SB 242084

Name: SB 242084
Brand: Tocris Bioscience
SKU: 2901
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2901

(1)

Citations (89)

COA / SDS

Selective 5-HT2C antagonist; brain penetrant

Key Product Details

Description:	Selective 5-HT_2C antagonist; brain penetrant
Chemical Name:	6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	467.78

View Full Technical Details for SB 242084

Technical Data
Citations / Reviews (1)

Biological Activity for SB 242084

SB 242084 is a 5-HT_2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT_2A and 5-HT_2B receptors respectively. Also displays selectivity over a range of other 5-HT, dopamine and adrenergic receptors. Brain penetrant; exerts anxiolytic-like activity.

Licensing Information

Sold with the permission of GlaxoSmithKline

Compound Libraries for SB 242084

SB 242084 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SB 242084

M. Wt	467.78
Formula	C₂₁H₁₉ClN₄O₂.2HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1049747-87-6
PubChem ID	16219981
InChi Key	GCMNSEILNIPNSX-UHFFFAOYSA-N
Smiles	O=C(N3C(C=C(Cl)C(C)=C4)=C4CC3)NC(C=C2)=CN=C2OC1=CC=CN=C1C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 242084

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.39	50

Preparing Stock Solutions for SB 242084

The following data is based on the product molecular weight 467.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.28 mL	21.38 mL	42.76 mL
2.5 mM	0.86 mL	4.28 mL	8.55 mL
5 mM	0.43 mL	2.14 mL	4.28 mL
25 mM	0.09 mL	0.43 mL	0.86 mL

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References for SB 242084

References are publications that support the biological activity of the product.

Kennet SB 242084, a selective and brain penetrant 5-HT_2C receptor antagonist. Neuropharmacology 1997 PMID: 9225286
Dalton Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse. Psychopharmacology 2006 PMID: 16470405
Bromidge 6-Chloro-5-methyl-1-[[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-indoline (SB-242084): the first selective and brain penetrant 5-HT_2C receptor antagonist. J.Med.Chem. 1997 PMID: 9357513