SB 290157 trifluoroacetate

Name: SB 290157 trifluoroacetate
Brand: Tocris Bioscience
SKU: 6860

Tocris Bioscience, part of Bio-Techne | Catalog # 6860

Citations (3)

COA / SDS

Potent C3a receptor antagonist

Key Product Details

Description:	Potent C3a receptor antagonist
Chemical Name:	N²-[2-(2,2-Diphenylethoxy)acetyl]-L-arginine trifluoroacetate
Purity:	≥97% (HPLC)
Molecular Weight:	526.51

View Full Technical Details for SB 290157 trifluoroacetate

Technical Data
Citations

Biological Activity for SB 290157 trifluoroacetate

SB 290157 trifluoroacetate is a potent C3a receptor antagonist (IC₅₀ values are 27 - 30 nM for C3a-induced Ca²⁺ mobilization in vitro and ex vivo). Inhibits C3a-induced chemotaxis in human mast cell line. Also inhibits tau hyperphosphorylation in vitro. Displays anti-inflammatory effects in animal models of airway inflammation and arthritis. Also inhibits glucose-induced insulin secretion and ATP production from ex vivo human and mouse pancreatic islets. Also exhibits C3a receptor agonist activity.

Technical Data for SB 290157 trifluoroacetate

M. Wt	526.51
Formula	C₂₂H₂₈N₄O₄.CF₃CO₂H
Storage	Desiccate at RT
Purity	≥97% (HPLC)
CAS Number	1140525-25-2
PubChem ID	16760645
InChi Key	ZJRMPPVJAQWGEG-FYZYNONXSA-N
Smiles	NC(NCCC[C@@H](C(O)=O)NC(COCC(C1=CC=CC=C1)C2=CC=CC=C2)=O)=N.FC(F)(C(O)=O)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 290157 trifluoroacetate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	52.65	100
	ethanol	52.65	100

Preparing Stock Solutions for SB 290157 trifluoroacetate

The following data is based on the product molecular weight 526.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.90 mL	9.50 mL	18.99 mL
5 mM	0.38 mL	1.90 mL	3.80 mL
10 mM	0.19 mL	0.95 mL	1.90 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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References for SB 290157 trifluoroacetate

References are publications that support the biological activity of the product.

Mathieu The C3a receptor antagonist SB 290157 has agonist activity. Immunol.Lett. 2005 PMID: 16154494
Atanes C3aR and C5aR1 act as key regulators of human and mouse β-cell function. Cell Mol.Life Sci. 2018 PMID: 28921001
Hu Complement C3a receptor antagonist attenuates tau hyperphosphorylation via glycogen synthase kinase 3β signaling pathways. Eur.J.Pharmacol. 2019 PMID: 30771350
Ames Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. J.Immunol. 2001 PMID: 11342658