SB 505124

Name: SB 505124
Brand: Tocris Bioscience
SKU: 3263

Tocris Bioscience, part of Bio-Techne | Catalog # 3263

Citations (39)

COA / SDS

Selective inhibitor of TGF-βRI, ALK4 and ALK7

Key Product Details

Description:	Selective inhibitor of TGF-βRI, ALK4 and ALK7
Chemical Name:	2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine
Purity:	≥98% (HPLC)
Molecular Weight:	335.4

View Full Technical Details for SB 505124

Technical Data
Citations

Biological Activity for SB 505124

SB 505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC₅₀ values are 47 and 129 nM for ALK5 and ALK4 respectively). Selectively inhibits signaling from TGF-β and activin; does not inhibit other ALK family members. Promotes adenine base editor activity in vivo and in vitro at 10 μM.

Compound Libraries for SB 505124

SB 505124 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for SB 505124

M. Wt	335.4
Formula	C₂₀H₂₁N₃O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	694433-59-5
PubChem ID	9858940
InChi Key	WGZOTBUYUFBEPZ-UHFFFAOYSA-N
Smiles	CC(C)(C)C1=NC(C2=CC(OCO4)=C4C=C2)=C(C3=NC(C)=CC=C3)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 505124

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.54	100
	2eq. HCl	33.54	100

Preparing Stock Solutions for SB 505124

The following data is based on the product molecular weight 335.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.98 mL	14.91 mL	29.82 mL
5 mM	0.60 mL	2.98 mL	5.96 mL
10 mM	0.30 mL	1.49 mL	2.98 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for SB 505124

References are publications that support the biological activity of the product.

Yang Small-molecule activators specific to adenine base editors through blocking the canonical TGF-β pathway. Nucleic Acids Res. 2022 PMID: 36043443
Hu Reactive oxygen species production via NADPH oxidase mediates TGF-β-induced cytoskeletal alterations in endothelial cells. Am.J.Physiol.Renal Physiol. 2005 PMID: 16159901
Noma The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis. Gastroenterology 2008 PMID: 18439605
Byfield SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7. Mol.Pharmacol. 2004 PMID: 14978253