SB 590885

Name: SB 590885
Brand: Tocris Bioscience
SKU: 2650
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2650

Citations (41)

COA / SDS

Potent B-Raf inhibitor

Key Product Details

Description:	Potent B-Raf inhibitor
Chemical Name:	5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime
Purity:	≥98% (HPLC)
Molecular Weight:	453.54

View Full Technical Details for SB 590885

Technical Data
Citations

Biological Activity for SB 590885

SB 590885 is a potent B-Raf inhibitor (K_d = 0.3 nM). Selective for B-Raf against 46 other kinases (K_{i app} values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively). Decreases anchorage-independent growth of melanoma cell lines. Inhibits ERK phosphorylation and proliferation in tumor cells expressing B-Raf^V600E. The compound can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data for SB 590885

M. Wt	453.54
Formula	C₂₇H₂₇N₅O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	405554-55-4
PubChem ID	11316960
InChi Key	DPCXEUSDRQOOGZ-QLYXXIJNSA-N
Smiles	CN(C)CCOC(C=C4)=CC=C4C1=NC(C3=CC=C(C(CC5)=NO)C5=C3)=C(C2=CC=NC=C2)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 590885

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.54	10

Preparing Stock Solutions for SB 590885

The following data is based on the product molecular weight 453.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.05 mL	110.24 mL	220.49 mL
0.5 mM	4.41 mL	22.05 mL	44.10 mL
1 mM	2.20 mL	11.02 mL	22.05 mL
5 mM	0.44 mL	2.20 mL	4.41 mL

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References for SB 590885

References are publications that support the biological activity of the product.

Takle The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg.Med.Chem.Lett. 2006 PMID: 16260133
Guan Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 2022 PMID: 35418683
King Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res. 2006 PMID: 17145850