SB 699551

Name: SB 699551
Brand: Tocris Bioscience
SKU: 3188

Tocris Bioscience, part of Bio-Techne | Catalog # 3188

Citations (9)

COA / SDS

Selective 5-ht5a antagonist

Key Product Details

Description:	Selective 5-ht_5a antagonist
Chemical Name:	N-[2-(Dimethylamino)ethyl]-N-[[4'-[[(2-phenylethyl)amino]methyl][1,1'-biphenyl]-4-yl]methyl]cyclopentanepropanamide dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	584.66

View Full Technical Details for SB 699551

Technical Data
Citations

Biological Activity for SB 699551

SB 699551 is a selective 5-ht_5a receptor antagonist (pK_i values are 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht_5a, 5-HT_1B/D, 5-HT_2A, 5-HT_2C, 5-HT_1A and 5-HT₇ receptors respectively).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for SB 699551

M. Wt	584.66
Formula	C₃₄H₄₅N₃O.2HCl
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	864741-95-7
PubChem ID	11983346
InChi Key	QJMKBIHLMPTYTI-UHFFFAOYSA-N
Smiles	O=C(CCC4CCCC4)N(CCN(C)C)CC(C=C2)=CC=C2C1=CC=C(CNCCC3=CC=CC=C3)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 699551

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	14.62	25
	ethanol	5.85	10

Preparing Stock Solutions for SB 699551

The following data is based on the product molecular weight 584.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	6.84 mL	34.21 mL	68.42 mL
1.25 mM	1.37 mL	6.84 mL	13.68 mL
2.5 mM	0.68 mL	3.42 mL	6.84 mL
12.5 mM	0.14 mL	0.68 mL	1.37 mL

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References for SB 699551

References are publications that support the biological activity of the product.

Thomas 5-ht_5A receptors as a therapeutic target. Pharmacol.Ther. 2006 PMID: 16516972
Corbett Discovery of a potent and selective 5-ht_5A receptor antagonist by high-throughput chemistry. Bioorg.Med.Chem.letts. 2005 PMID: 16002289
Thomas SB-69951-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: evidence for an auto Neuropharmacology 2006 PMID: 16846620