SC 514

Name: SC 514
Brand: Tocris Bioscience
SKU: 3318
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3318

(1)

Citations (20)

COA / SDS

IKKβ inhibitor; attenuates NF-κB-induced gene expression

Discontinued Product

3318 has been discontinued. View all IkB Kinase Inhibitors products.

Key Product Details

Description:	IKKβ inhibitor; attenuates NF-κB-induced gene expression
Chemical Name:	4-Amino-[2',3'-bithiophene]-5-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	224.3

View Full Technical Details for SC 514

Technical Data
Citations / Reviews (1)

Biological Activity for SC 514

SC 514 is an orally active, ATP-competitive IKKβ inhibitor (IC₅₀ = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. Attenuates NF-κB-induced gene expression of IL-6, IL-8 and COX-2 in synovial fibroblasts (IC₅₀ values are 20, 20 and 8 μM respectively). Reduces iNOS induction and exhibits anti-inflammatory activity in vivo.

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Technical Data for SC 514

M. Wt	224.3
Formula	C₉H₈N₂OS₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	354812-17-2
PubChem ID	2807869
InChi Key	BMUACLADCKCNKZ-UHFFFAOYSA-N
Smiles	NC1=C(C(N)=O)SC(C2=CSC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SC 514

References are publications that support the biological activity of the product.

Gomez Selective inhibition of kappa B kinase-β aborgates induction of nitric oxide synthase in lipopolysaccharide-stimulated rat aortic smooth muscle cells. Br.J.Pharmacol. 2005 PMID: 15997236
Baxter Hit-to-lead studies: the discovery of potent, orally active thiophenecarboxamide IKK-2 inhibitors. Bioorg.Med.Chem.Letts.
Kishore A selective IKK-2 inhibitor blocks NF-κB-dependent gene expression in interleukin-1β-stimulated synovial fibroblasts. J.Biol.Chem. 2003 PMID: 12813046