SD 1008

Name: SD 1008
Brand: Tocris Bioscience
SKU: 3035

Tocris Bioscience, part of Bio-Techne | Catalog # 3035

Citations (8)

COA / SDS

JAK2/STAT3 signaling pathway inhibitor

Key Product Details

Description:	JAK2/STAT3 signaling pathway inhibitor
Chemical Name:	(1R,5R,6R,7S)-rel-4-Oxo-8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid 6,7-dimethyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	329.35

View Full Technical Details for SD 1008

Technical Data
Citations

Biological Activity for SD 1008

SD 1008 is a JAK2/STAT3 signaling pathway inhibitor. Inhibits activation of STAT3, JAK2 and Src. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

Compound Libraries for SD 1008

SD 1008 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SD 1008

M. Wt	329.35
Formula	C₁₈H₁₉NO₅
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	960201-81-4
PubChem ID	90488795
InChi Key	XJLVVXLRQMISCS-ROINDZCWSA-N
Smiles	O=C1C=C[C@@H]2[C@@H]([C@](OC)=O)[C@@H]([C@](OC)=O)[C@H]1N2CC3=CC=CC=C3.O=C4C=C[C@H]5[C@H](C(OC)=O)[C@H](C(OC)=O)[C@@H]4N5CC6=CC=CC=C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SD 1008

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.94	100
	ethanol	1.65	5

Preparing Stock Solutions for SD 1008

The following data is based on the product molecular weight 329.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.04 mL	15.18 mL	30.36 mL
5 mM	0.61 mL	3.04 mL	6.07 mL
10 mM	0.30 mL	1.52 mL	3.04 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

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References for SD 1008

References are publications that support the biological activity of the product.

Duan 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel Janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells. Mol.Pharmacol. 2007 PMID: 17675586