SD 2590 hydrochloride

Name: SD 2590 hydrochloride
Brand: Tocris Bioscience
SKU: 4775

Tocris Bioscience, part of Bio-Techne | Catalog # 4775

COA / SDS

Potent MMP inhibitor

Key Product Details

Description:	Potent MMP inhibitor
Alternative Names:	SC 78080
Chemical Name:	N-Hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-4-piperidinecarboxamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	554.96

View Full Technical Details for SD 2590 hydrochloride

Technical Data
Citations

Biological Activity for SD 2590 hydrochloride

SD 2590 hydrochloride is a potent MMP inhibitor (IC₅₀ values are <0.1, <0.1, 0.18, 1.7, 13 and 28.7 nM for MMP-2, -13, -9, -8, -14 and -3 respectively). Exhibits 100,000-fold selectivity for MMP-2 and -13 over MMP-1. Reduces left ventricular dilation in a myocardial infarction rat model. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Compound Libraries for SD 2590 hydrochloride

SD 2590 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SD 2590 hydrochloride

M. Wt	554.96
Formula	C₂₂H₂₅F₃N₂O₇S.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	226395-93-3
PubChem ID	9893894
InChi Key	HJJOIVGDTLHVTK-UHFFFAOYSA-N
Smiles	O=S(C1(C(NO)=O)CCN(CCOC)CC1)(C2=CC=C(OC3=CC=C(OC(F)(F)F)C=C3)C=C2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SD 2590 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	55.5	100
	DMSO	55.5	100

Preparing Stock Solutions for SD 2590 hydrochloride

The following data is based on the product molecular weight 554.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.80 mL	9.01 mL	18.02 mL
5 mM	0.36 mL	1.80 mL	3.60 mL
10 mM	0.18 mL	0.90 mL	1.80 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for SD 2590 hydrochloride

References are publications that support the biological activity of the product.

Becker Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J.Med.Chem. 2010 PMID: 20726512