Selinexor

Name: Selinexor
Brand: Tocris Bioscience
SKU: 7760

Tocris Bioscience, part of Bio-Techne | Catalog # 7760

COA / SDS

Selective exportin 1 (XPO1/CRM1) inhibitor

Key Product Details

Description:	Selective exportin 1 (XPO1/CRM1) inhibitor
Chemical Name:	(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide
Purity:	≥98% (HPLC)
Molecular Weight:	443.31

View Full Technical Details for Selinexor

Technical Data
Citations

Biological Activity for Selinexor

Selinexor is an inhibitor of the exportin 1 (XPO1/CRM1) nuclear exporter. Shows selectivity for TNBC over ER-positive breast cancer cell lines (IC₅₀ values are 11-550 nM and >1000 nM, respectively), and reduces growth of xenografts. Inhibits growth of thyroid cancer cell lines (IC₅₀ = 150-500 nM), potentiates the anti-tumor effects of Olaparib (Cat. No. 7579) in ovarian cancer and breast cancer. Also a potent inhibitor of SARS-CoV-2 replication in vitro (EC₅₀ = 10 nM) and downregulates the production of pro-inflammatory cytokines including TNF-α and IL-6.

Technical Data for Selinexor

M. Wt	443.31
Formula	C₁₇H₁₁F₆N₇O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1393477-72-9
PubChem ID	71481097
InChi Key	DEVSOMFAQLZNKR-RJRFIUFISA-N
Smiles	O=C(NNC1=NC=CN=C1)/C=C\N(C=N2)N=C2C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Selinexor

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	44.33	100
	ethanol	22.17	50

Preparing Stock Solutions for Selinexor

The following data is based on the product molecular weight 443.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.28 mL	22.56 mL
5 mM	0.45 mL	2.26 mL	4.51 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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References for Selinexor

References are publications that support the biological activity of the product.

Marijon Selinexor, a selective inhibitor of nuclear export, enhances the anti-tumor activity of olaparib in triple negative breast cancer regardless of BRCA1 mutation status. Oncotarget. 2021 PMID: 34504648
Kashyap Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo. Antiviral Res. 2021 PMID: 34157321
Arango Selinexor (KPT-330) demonstrates anti-tumor efficacy in preclinical models of triple-negative breast cancer. Breast Cancer Res. 2017 PMID: 28810913