SEW 2871

Name: SEW 2871
Brand: Tocris Bioscience
SKU: 2284

Tocris Bioscience, part of Bio-Techne | Catalog # 2284

Citations (30)

COA / SDS

Cell-permeable, selective S1P1 receptor agonist

Key Product Details

Description:	Cell-permeable, selective S1P₁ receptor agonist
Chemical Name:	5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]1,2,4-oxadiazole
Purity:	≥99% (HPLC)
Molecular Weight:	440.36

View Full Technical Details for SEW 2871

Technical Data
Citations

Biological Activity for SEW 2871

SEW 2871 is a novel, potent and selective sphingosine-1-phosphate 1 (S1P₁) receptor agonist. Activates S1P₁ receptor with an EC₅₀ of 13 nM, but does not activate S1P₂, S1P₃, S1P₄ or S1P₅ receptors at concentrations up to 10 μM. Cell-permeable and active in vivo.

Technical Data for SEW 2871

M. Wt	440.36
Formula	C₂₀H₁₀F₆N₂OS
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	256414-75-2
PubChem ID	4077460
InChi Key	OYMNPJXKQVTQTR-UHFFFAOYSA-N
Smiles	FC(F)(F)C1=C(C=C(S1)C1=NC(=NO1)C1=CC(=CC=C1)C(F)(F)F)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SEW 2871

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	8.81	20
	ethanol	8.81	20

Preparing Stock Solutions for SEW 2871

The following data is based on the product molecular weight 440.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.35 mL	56.77 mL	113.54 mL
1 mM	2.27 mL	11.35 mL	22.71 mL
2 mM	1.14 mL	5.68 mL	11.35 mL
10 mM	0.23 mL	1.14 mL	2.27 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for SEW 2871

References are publications that support the biological activity of the product.

Sanna Sphingosine 1-phosphate (S1P) receptor subtypes S1P₁ and S1P₃, respectively, regulate lymphocyte recirculation and heart rate. J.Biol.Chem. 2004 PMID: 14732717
Bolick Sphingosine-1-phosphate prevents tumor necrosis factor-α-mediated monocyte adhesion to aortic endothelium in mice. Arterioscler.Thromb.Vasc.Biol. 2005 PMID: 15761190
Hale A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists. J.Med.Chem. 2004 PMID: 15615513