SF 11

Name: SF 11
Brand: Tocris Bioscience
SKU: 3898

Tocris Bioscience, part of Bio-Techne | Catalog # 3898

Citations (4)

COA / SDS

NPY Y2 receptor antagonist

Key Product Details

Chemical Name:	N-(4-Ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide
Purity:	≥99%
Molecular Weight:	446.6 kDa

View Full Technical Details for SF 11

Technical Data
Citations

Biological Activity for SF 11

SF 11 is an NPY Y₂ antagonist (IC₅₀ = 199 nM). Displays no affinity for Y₁ receptor at concentrations up to 35 μM. Causes significant lethality in mice. Displays antidepressant effects in rats. Brain penetrant.

Technical Data for SF 11

M. Wt	446.6 kDa
Formula	C₂₇H₃₀N₂O₂S
Storage	Store at +4°C
Purity	≥99%
CAS Number	443292-81-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SF 11

Solubility

Soluble Soluble to 100 mM in DMSO and to 50 mM in ethanol

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References for SF 11

References are publications that support the biological activity of the product.

Kawabe, Tetsuya, Kawabe, Kazumi, Sapru, Hreday N Cardiovascular responses to chemical stimulation of the hypothalamic arcuate nucleus in the rat: role of the hypothalamic paraventricular nucleus. PLoS ONE, 2012;7(9):e45180. 2012 PMID: 23028831
Domin et al. Characterization of the brain penetrant neuropeptide Y Y₂ receptor antagonist SF-11. ACS Chem.Neurosci., 2019;10:3454 PMID: 31267743
Brothers et al. Selective and brain penetrant neuropeptide Y Y₂ receptor antagonists discovered by whole-cell high-throughput screening. Mol.Pharmacol., 2010;77:46 PMID: 19837904