SF 1670

Name: SF 1670
Brand: Tocris Bioscience
SKU: 5020

Tocris Bioscience, part of Bio-Techne | Catalog # 5020

Citations (6)

COA / SDS

PTPN2 and PTEN inhibitor

Key Product Details

Description:	PTPN2 and PTEN inhibitor
Alternative Names:	PTP Inhibitor XIX
Chemical Name:	N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethylpropanamide
Purity:	≥98% (HPLC)
Molecular Weight:	307.34

View Full Technical Details for SF 1670

Technical Data
Citations

Biological Activity for SF 1670

SF 1670 is a PTPN2 and PTEN inhibitor (IC₅₀values are 0.95 and 1.78 μM, respectively). Increases fMLP-elicited PIP₃ signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice. Also inhibits CD45.

Technical Data for SF 1670

M. Wt	307.34
Formula	C₁₉H₁₇NO₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	345630-40-2
PubChem ID	9926586
InChi Key	VZQDDSYKVYARDW-UHFFFAOYSA-N
Smiles	O=C2C1=CC=CC=C1C3=C(C=C(NC(C(C)(C)C)=O)C=C3)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SF 1670

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	30.73	100

Preparing Stock Solutions for SF 1670

The following data is based on the product molecular weight 307.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.25 mL	16.27 mL	32.54 mL
5 mM	0.65 mL	3.25 mL	6.51 mL
10 mM	0.33 mL	1.63 mL	3.25 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for SF 1670

References are publications that support the biological activity of the product.

Le Inhibition of protein tyrosine phosphatase non-receptor type 2 by PTP inhibitor XIX: Its role as a multiphosphatase inhibitor. BMB Rep. 2017 PMID: 28228214
Li Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood 2011 PMID: 21521784