SGC 3027

Name: SGC 3027
Brand: Tocris Bioscience
SKU: 6825

Tocris Bioscience, part of Bio-Techne | Catalog # 6825

COA / SDS

Potent and selective PRMT7 inhibitor

Key Product Details

Description:	Potent and selective PRMT7 inhibitor
Chemical Name:	N-(4-((((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)butyl)-N-((4'-chloro-[1,1'-biphenyl]-3-yl)methyl)-3-methyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide
Purity:	≥97% (HPLC)
Molecular Weight:	787.37

View Full Technical Details for SGC 3027

Technical Data
Citations

Biological Activity for SGC 3027

SGC 3027 is a potent and selective PRMT7 inhibitor (IC₅₀ < 2.5 nM); pro-drug of SGC 8158. Methylates H2B (23-37). Exhibits > 40-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits methylation of HSP70 in C2C12 cells.

Negative control, SGC 3027N (Cat. No. 6838) also available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 3027 probe summary on the SGC website.

Technical Data for SGC 3027

M. Wt	787.37
Formula	C₄₁H₄₇ClN₆O₆S
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	2624313-13-7
PubChem ID	137333447
InChi Key	MLJVGAYSVYMPSB-MSUKGTQXSA-N
Smiles	ClC1=CC=C(C2=CC(CN(CCCCSC[C@H]3O[C@@H](N4C=NC5=C4N=CN=C5N)[C@H](O)[C@@H]3O)C(CC(C6=C(C)C(C(C)=C(C)C6=O)=O)(C)C)=O)=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SGC 3027

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	78.74	100

Preparing Stock Solutions for SGC 3027

The following data is based on the product molecular weight 787.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.27 mL	6.35 mL	12.70 mL
5 mM	0.25 mL	1.27 mL	2.54 mL
10 mM	0.13 mL	0.64 mL	1.27 mL
50 mM	0.03 mL	0.13 mL	0.25 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for SGC 3027

References are publications that support the biological activity of the product.

Szewczyk Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress responses. Nat.Commun. 2020 PMID: 32409666