SGC-CBP30

Name: SGC-CBP30
Brand: Tocris Bioscience
SKU: 4889

Tocris Bioscience, part of Bio-Techne | Catalog # 4889

(1)

Citations (10)

COA / SDS

Potent CBP/p300 BRD inhibitor

Key Product Details

Chemical Name:	2-[2-(3-Chloro-4-methoxyphenyl)ethyl]-5-(dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-1,3-benzodiazole
Purity:	≥98%

View Full Technical Details for SGC-CBP30

Technical Data
Citations / Reviews (1)

Biological Activity for SGC-CBP30

SGC-CBP30 is a potent CBP/p300 bromodomain (BRD) inhibitor (K_d values are 21 and 32 nM for CBP and p300 BRDs respectively). Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively. Accelerates FRAP recovery in cells at a concentration of 1 μM. SGC-CBP30 can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.

Technical Data for SGC-CBP30

Formula	C₂₈H₃₃ClN₄O₃
Storage	Store at +4°C
Purity	≥98%
CAS Number	1613695-14-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SGC-CBP30

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for SGC-CBP30

References are publications that support the biological activity of the product.

Hay et al. Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains. J.Am.Chem.Soc., 2014;136:9308 PMID: 24946055
Gallenkamp et al. Bromodomains and their pharmacological inhibitors. ChemMedChem, 2014;9:438 PMID: 24497428
Hammitzsch et al. CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses. Proc.Natl.Acad.Sci.U.S.A., 2015;112:10768 PMID: 26261308

SGC-CBP30

Tocris Bioscience, part of Bio-Techne | Catalog # 4889

Key Product Details

Biological Activity for SGC-CBP30

Technical Data for SGC-CBP30

Solubility for SGC-CBP30

Dilution Calculator

Reconstitution Calculator

References for SGC-CBP30

Product Documents for SGC-CBP30

COA

Certificate of Analysis

SDS

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