Silodosin

Name: Silodosin
Brand: Tocris Bioscience
SKU: 6663

Tocris Bioscience, part of Bio-Techne | Catalog # 6663

Citations (2)

COA / SDS

Selective α1A antagonist

Key Product Details

Chemical Name:	2,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carboxamide
Purity:	≥98%

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Technical Data
Citations

Biological Activity for Silodosin

Silodosin is a selective α_1A adrenoceptor antagonist (K_i = 0.036 nM). Displays >55 fold selectivity for α_1A over α_1B and α_1D. Inhibits norepinephrine-induced [Ca²⁺]_I increase in α_1A expressing CHO cells (IC₅₀ = 0.32 nM). Inhibits norepinephrine-induced contraction of isolated human prostate tissue.

Technical Data for Silodosin

Formula	C₂₅H₃₂F₃N₃O₄
Storage	Store at -20°C
Purity	≥98%
CAS Number	160970-54-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Silodosin

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for Silodosin

References are publications that support the biological activity of the product.

Shibata et al. KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues. Mol.Pharmacol., 1995;48:250 PMID: 7651358
Moriyama et al. KMD-3213, a novel alpha1A-adrenoceptor antagonist, potently inhibits the functional alpha1-adrenoceptor in human prostate. Eur.J.Pharmacol., 1997;331:39 PMID: 9274928

Silodosin

Tocris Bioscience, part of Bio-Techne | Catalog # 6663

Key Product Details

Biological Activity for Silodosin

Technical Data for Silodosin

Solubility for Silodosin

Dilution Calculator

Reconstitution Calculator

References for Silodosin

Product Documents for Silodosin

COA

Certificate of Analysis

SDS

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