Simvastatin

Name: Simvastatin
Brand: Tocris Bioscience
SKU: 1965

Tocris Bioscience, part of Bio-Techne | Catalog # 1965

(1)

Citations (27)

COA / SDS

HMG-CoA reductase inhibitor

Key Product Details

Chemical Name:	(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate
Purity:	≥98%
Molecular Weight:	418.57 kDa

View Full Technical Details for Simvastatin

Technical Data
Citations / Reviews (1)

Biological Activity for Simvastatin

Simvastatin is a HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Simvastatin is also an AMPK activator. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, induction of ferroptosis, inhibition of autophagy, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.Simvastatin acts synergistically with ABL allosteric inhibitors GNF 5 (Cat. No. 1965) to enhance apoptosis of metastatic lung cancer cells in mice.

Technical Data for Simvastatin

M. Wt	418.57 kDa
Formula	C₂₅H₃₈O₅
Storage	Desiccate at -20°C
Purity	≥98%
CAS Number	79902-63-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Simvastatin

Solubility

Soluble Soluble to 50 mM in DMSO and to 75 mM in ethanol

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References for Simvastatin

References are publications that support the biological activity of the product.

K Zhang, W Song, D Li, X Jin Apigenin in the regulation of cholesterol metabolism and protection of blood vessels Exp Ther Med, 2017;13(5):1719-1724. 2017 PMID: 28565758
Garrett et al. STAT and bone formation. Curr.Pharm.Des., 2001;7:715 PMID: 11405194
Kaushal et al. Potential anticancer effects of STAT: fact or fiction? Endothelium, 2003;10:49 PMID: 12699077
White Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein modulation. J.Clin.Pharmacol., 1999;39:111 PMID: 11563401
Reinoso et al. Preclinical pharmacokinetics of STAT. Methods Find.Exp.Clin.Pharmacol., 2002;24:593 PMID: 12616706